Carcinogenic gut microbes

Janelle Arthur, Ph.D.
Assistant Professor of Microbiology and Immunology
UNC-Chapel Hill School of Medicine

Janelle’s group seeks to understand how inflammation alters the pro-carcinogenic capabilities of the microbiota, with the long-term goal of targeting resident microbes as a preventative and therapeutic strategy to lessen inflammation and reduce the risk of colorectal cancer.

They are focus on clinical strains of intestinal E. coli isolated directly from human inflammatory bowel disease (IBD) patients, who are known to experience a high risk of colorectal cancer.  Janelle’s goal is to uncover novel microbial targets will enable us to manipulate the intestinal microbiota as a therapeutic target for human digestive diseases and cancer.