Jenna McHenry – March 6th, 2018

Dr. Jenna McHenry, Assistant Professor of Psychology and Neuroscience at Duke University, starting Fall 2018

Hormonal regulation of a hypothalamic social reward circuit

Dr. Jenna McHenry was recently hired as an Assistant Professor of Psychology and Neuroscience at Duke University starting Fall 2018. She is currently completing her post-doctoral fellowship at the University of North Carolina- Chapel Hill in Dr. Garret Stuber’s laboratory. Her post-doctoral work has focused on investigating the neural circuitry that links social and emotional processing within the brain. As evident in reproductive mood disorders such as post-partum depression and premenstrual dysphoric disorder, hormonal flux can cause affective disorders. Dr. McHenry’s post-doctoral work has focused on studying the neural circuits—specifically the circuits involving the medial preoptic area (mPOA)— that regulate hormone mediated reward programming and sex specific behavior. In work published in Nature Neuroscience in 2017, Dr. McHenry used in vivo two-photon imaging in awake mice to identify a subset of neurotensin-expressing mPOA neurons that interface with the ventral tegmental area (VTA) to form a socially engaged reward circuit. By recording from these neurons both at different times in the female reproductive cycle and after ovariectomy, she found this subset of neurons is steroid-responsive, indicating steroids modulate social encoding. As an extension of her post-doctoral work, Dr. McHenry’s central research question in her laboratory will be to understand how social processing neurons are intertwined with or embedded into positive and negative valence systems. Further, her lab will investigate the interplay between social and non-social reward circuits. Her lab will use a combination of advanced techniques including freely moving calcium imaging and optogenetics to investigate these questions. We look forward to the exciting research that Dr. McHenry will bring to Duke as a new faculty member.

See Dr. McHenry’s work here.