Jun 2018 – Robert Heuckeroth

Dr. Robert Heuckeroth, M.D. Ph.D. is a Professor of Pediatrics and practicing pediatric gastroenterologist at The Children’s Hospital of Philadelphia- Research Institute. His research aims to better understand enteric nervous system anatomy and development to translate into clinical pathology. One of the diseases he studies is Hirschsprung’s disease, a disease in which the distal portion of the bowel is aganglionic due to defective nerve cell migration. This lack of nerve cells prevents the bowel from working correctly causing significant obstruction. Dr. Heuckeroth has provided insight into how the enteric nervous system develops and what external factors affect its development. Hirschsprung’s disease is commonly associated with RET mutations, as RET signaling is critical for enteric nervous system proliferation, migration, and network formation. Dr. Heuckeroth’s work has identified glial cell line-derived neurotrophic factor (GDNF) as an important molecule in establishing enteric nervous system structure and function. His lab has also identified external, prenatal factors that promote proper enteric nervous system development. Vitamin A is essential for enteric nervous system development. Additionally, they have shown that maternal usage of ibuprofen slows migration of enteric nervous system precursor cells and predisposes for Hirschsprung’s disease. They will continue to investigate the internal and external factors that contribute to enteric nervous system development with hopes of both preventing childhood bowel motility disorders.